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Purchase AccessThe findings from the study were:
1. Participants diagnosed with ASDs had significantly (p<0.001) decreased plasma-reduced GSH, plasma cysteine, plasma taurine, serum/plasma sulfate, and serum/plasma-free sulfate relative to controls.
2. Participants diagnosed with ASDs had significantly (p<0.001) increased plasma GSSG relative to controls.
3. Participants with severe ASDs had significantly increased urinary porphyrins associated with mercury intoxication (pentacarboxyporphyrin, precoproporphyrin and coproporphyrin) in comparison to participants with mild ASDs, whereas other urinary porphyrins were similar in both groups.
4. Mercury-associated urinary porphyrins were significantly correlated with increasing CARS scores and GSSG levels, whereas other urinary porphyrins did not show these relationships.
5. Participants with ASDs had significantly increased levels of three urinary porphyrins known to be associated with Hg intoxication, pentacarboxyporphyrin, precoproporphyrins and coproporphyrins, in comparison to the levels for these in the typically developing children. No significant differences were found in non-Hg- associated urinary porphyrins (uroporphyrins, and 6- and 7-carboxyporphyrins).
6. Participants’ overall ATEC scores and their scores on each of the ATEC subscales (Speech/Language, Sociability, Sensory/Cognitive Awareness, and Health/Physical/Behavior) were linearly related to urinary porphyrins associated with mercury toxicity.
7. Typically developing children with less mercury exposure (i.e., less exposure to mercury in vaccines and mercury from coal-burning) show a significantly decreased body-burden of mercury in comparison to the body-burden of mercury in typically developing children with greater exposure.
Learning Objectives:
Content Area: Current Biomedical Research
Janet Kern, Ph.D.
Director
Genetic Consultants of Dallas